What is Corneal Cross-Linking?
Corneal collagen cross-linking is a medical procedure that combines the use of ultra-violet light and riboflavin (vitamin B2) drops.
- Creates new corneal collagen cross-links
- Results in a shortening and thickening of the collagen fibrils
- Leads to the stiffening of the cornea
Mechanism of Action
Riboflavin 5’-phosphate sodium (Vitamin B2) is the precursor of two coenzymes, flavin adenine dinucleotide and flavin mononucleotide, which catalyze oxidation/reduction reactions involved in a number of metabolic pathways.
Under the conditions used for corneal collagen cross-linking, riboflavin 5’-phosphate functions as a photoenhancer and generates singlet oxygen which is responsible for the cross-linking.