Corneal Collagen Crosslinking

What is Corneal Cross-Linking?

Corneal collagen cross-linking is a medical procedure that combines the use of ultra-violet light and riboflavin (vitamin B2) drops.

Corneal cross-linking¹:
  • Creates new corneal collagen cross-links
  • Results in a shortening and thickening of the collagen fibrils
  • Leads to the stiffening of the cornea

Mechanism of Action

Riboflavin 5’-phosphate sodium (Vitamin B2) is the precursor of two coenzymes, flavin adenine dinucleotide and flavin mononucleotide, which catalyze oxidation/reduction reactions involved in a number of metabolic pathways.

Under the conditions used for corneal collagen cross-linking, riboflavin 5’-phosphate functions as a photoenhancer and generates singlet oxygen which is responsible for the cross-linking.

Skip to content